Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Jun;19(2):367-71.
doi: 10.1037/0882-7974.19.2.367.

Apolipoprotein e gene variability and cognitive functions at age 79: a follow-up of the Scottish mental survey of 1932

Ian J Deary  1 , Martha C Whiteman, Alison Pattie, John M Starr, Caroline Hayward, Alan F Wright, Peter M Visscher, Maria C Tynan, Lawrence J Whalley
Affiliations
Free article

Apolipoprotein e gene variability and cognitive functions at age 79: a follow-up of the Scottish mental survey of 1932

Ian J Deary et al. Psychol Aging. 2004 Jun.
Free article

Abstract

Apolipoprotein E (APOE) genotype is a possible influence on nonpathological cognitive aging. The authors studied 462 community-dwelling, 79-year-old people born in 1921, whose childhood IQ had been assessed in the Scottish Mental Survey of 1932 (Scottish Council for Research in Education, 1933). Adjusting for sex, childhood IQ, and self-reported illnesses, the authors found that those with an APOE e4 allele had significantly lower Wechsler Logical Memory (D. Wechsler, 1987) scores than those without an e4 allele. Those people with APOE s2/e3 genotypes had significantly higher Wechsler Logical Memory scores than e3/s3, who were significantly higher than e3/e4. Neither nonverbal reasoning nor verbal fluency were affected. In this sample, APOE genotype contributed to verbal memory in old age.

PubMed Disclaimer

Publication types

Substances