Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Jun;13(3):139-43.
doi: 10.1080/09511920410001713565.

Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors

Marco A Campos  1 , Ricardo T Gazzinelli
Affiliations
Review

Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors

Marco A Campos et al. Mediators Inflamm. 2004 Jun.

Abstract

Trypanosoma cruzi is the etiologic agent of Chagas' disease, a parasitic disease of enormous importance in Latin America. Herein we review the studies that revealed the receptors from innate immunity that are involved in the recognition of this protozoan parasite. We showed that the recognition of T. cruzi and its components occurs through Toll-like receptors (TLR) 2/CD14. Further, we showed in vivo the importance of the myeloid differentiation factor (MyD88), an adapter protein essential for the function of TLRs, in determining the parasitemia and mortality rate of mice infected with T. cruzi. We also discuss the implications of these findings in the pathophysiology of Chagas' disease.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Annu Rev Immunol. 1983;1:335-59 - PubMed
    1. Cell. 1985 Oct;42(3):779-89 - PubMed
    1. Nature. 1995 Jan 19;373(6511):199-200 - PubMed
    1. Cell. 1996 Sep 20;86(6):973-83 - PubMed
    1. Nature. 1997 Jul 24;388(6640):394-7 - PubMed

Publication types