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. 2004 Jul 7;126(26):8126-7.
doi: 10.1021/ja047407e.

Catalytic generation of activated carboxylates: direct, stereoselective synthesis of beta-hydroxyesters from epoxyaldehydes

Kenneth Yu-Kin Chow  1 , Jeffrey W Bode
Affiliations

Catalytic generation of activated carboxylates: direct, stereoselective synthesis of beta-hydroxyesters from epoxyaldehydes

Kenneth Yu-Kin Chow et al. J Am Chem Soc. .

Abstract

The catalytic generation of activated carboxylates from epoxyaldehydes enables the direct, stereoselective synthesis of beta-hydroxyesters under mild, convenient reaction conditions. In addition to providing a new method for the synthesis of anti-aldol adducts, this chemistry unveils a mechanistically viable solution to the catalytic, waste-free synthesis of esters.

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