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. 2004 Aug 2;14(15):4107-11.
doi: 10.1016/j.bmcl.2004.04.087.

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

Ahmed Kamal  1 , O Srinivas, P Ramulu, G Ramesh, P Praveen Kumar
Affiliations

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

Ahmed Kamal et al. Bioorg Med Chem Lett. .

Abstract

Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

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