Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Jun;10(3):114-7.

Enfuvirtide

[Article in Czech, English]
Ladislav Machala  1
Affiliations
  • PMID: 15227601

Enfuvirtide

[Article in Czech, English]
Ladislav Machala. Klin Mikrobiol Infekc Lek. 2004 Jun.

Abstract

Enfuvirtide is the first representative of a new group of antiretrovirals - fusion inhibitors, which was approved for clinical use. Due to its attachment to the HR1 domain of HIV glycoprotein gp 41 enfuvirtide blocks the fusion between the virus and the target cell. Enfuvirtide is chemically a synthetic peptide consisting of 36 amino acids which is not stable in GIT and must be administered only subcutaneously. Enfuvirtide has been registered for the use as salvage therapy of patients with multiresistance, for who it is not possible to constitute an effective combination of other available antiretrovirals.

PubMed Disclaimer