[Mechanisms of tissue repair]

Abstract

Wound healing is critical for survival. The damaged tissue is usually replaced by connective tissue, which forms permanent scar. This causes the impairment of organ function. The scar is the effect of synthesis and degradation of extracellular matrix. Many factors are involved in the process of wound healing, among them growth factors: TGF-beta and PDGF and proteolytic enzymes such as elastase and collagenase. Further studies for the mechanisms leading to scar formation, factors that play role in this process and interactions among them could provide basis for the therapeutic modification and outcome of wound healing.