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Review
. 2004 Aug 17;101(33):11943-8.
doi: 10.1073/pnas.0402416101. Epub 2004 Jul 1.

Contiguous stereogenic quaternary carbons: a daunting challenge in natural products synthesis

Emily A Peterson  1 , Larry E Overman
Affiliations
Review

Contiguous stereogenic quaternary carbons: a daunting challenge in natural products synthesis

Emily A Peterson et al. Proc Natl Acad Sci U S A. .

Abstract

One element of structure that invariably increases the difficulty of a chemical synthesis is the presence in the target molecule of contiguous all-carbon quaternary stereocenters. This Perspective will examine the most useful transformations and strategies devised recently for directly assembling this structural unit.

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