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. 2004 Jul 2;305(5680):103-6.
doi: 10.1126/science.1096983.

Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase

Chieh Chang  1 , Timothy W Yu, Cornelia I Bargmann, Marc Tessier-Lavigne
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Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase

Chieh Chang et al. Science. .

Abstract

During axon guidance, the ventral guidance of the Caenorhabditis elegans anterior ventral microtubule axon is controlled by two cues, the UNC-6/netrin attractant recognized by the UNC-40/DCC receptor and the SLT-1/slit repellent recognized by the SAX-3/robo receptor. We show here that loss-of-function mutations in clr-1 enhance netrin-dependent attraction, suppressing ventral guidance defects in slt-1 mutants. clr-1 encodes a transmembrane receptor protein tyrosine phosphatase (RPTP) that functions in AVM to inhibit signaling through the DCC family receptor UNC-40 and its effector, UNC-34/enabled. The known effects of other RPTPs in axon guidance could result from modulation of guidance receptors like UNC-40/DCC.

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