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Case Reports
. 2004 Jun;23(6):607-9.
doi: 10.1016/j.annfar.2004.04.012.

[A case of anaphylactic shock with tranexamique acid (Exacyl)]

[Article in French]
M-M Lucas-Polomeni  1 , Y Delaval, P Menestret, P Delaval, C Ecoffey
Affiliations
Case Reports

[A case of anaphylactic shock with tranexamique acid (Exacyl)]

[Article in French]
M-M Lucas-Polomeni et al. Ann Fr Anesth Reanim. 2004 Jun.

Abstract

A 72-year-old male patient was scheduled for coronary artery bypass graft surgery because of severe three-vessel disease. Induction of anaesthesia was uneventful. Following bolus infusion of tranexamic acid (Exacyl), the patient presented clinical signs consistent with anaphylactic shock. Surgery was postponed and the patient recovered without sequaelae. Allergological investigations (cutaneous tests, serum IgE concentrations, in vitro histamine-release tests) suggest that this is the first reported case of anaphylactic shock to tranexamic acid. Several weeks later, the patient underwent surgery with a similar anaesthetic regimen and the clinical course was uneventful.

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