doi: 10.1007/s0054000040265.
Effects of midazolam on the threshold of lidocaine-induced seizures in the dog--comparison with diazepam
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- PMID: 15235984
- DOI: 10.1007/s0054000040265
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Effects of midazolam on the threshold of lidocaine-induced seizures in the dog--comparison with diazepam
J Anesth.
1990 Jul.
Abstract
The anticonvulsive effect of midazolam was compared with that of diazepam in ten dogs. Lidocaine-induced seizure waves on the electroencephalogram were used to observe the suppressive effect of the drugs. Midazolam, 0.2 mg.kg(-1), was found to possess a stronger suppressive effect against lidocaine-induced seizures than the same dose of diazepam. These two drugs showed to possess similar effects on cerebral and systemic circulations and cerebral metabolism during seizures.
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