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. 2004 Jul;56(1):129-32.
doi: 10.1002/ana.20153.

Is benign rolandic epilepsy genetically determined?

Lata Vadlamudi  1 , A Simon Harvey, Mary M Connellan, Roger L Milne, John L Hopper, Ingrid E Scheffer, Samuel F Berkovic
Affiliations

Is benign rolandic epilepsy genetically determined?

Lata Vadlamudi et al. Ann Neurol. 2004 Jul.

Abstract

Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0-0.4) for BRE compared with 0.7 (95% CI, 0.5-0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored.

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Comment in

  • Genetic influence on rolandic epilepsy.
    Bali B, Kugler SL, Pal DK. Bali B, et al. Ann Neurol. 2005 Mar;57(3):464-5; author reply 465. doi: 10.1002/ana.20399. Ann Neurol. 2005. PMID: 15732105 No abstract available.

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