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. 2004 Jul 6:4:22.
doi: 10.1186/1471-2334-4-22.

Chronological changes of incidence and prognosis of children with asymptomatic congenital cytomegalovirus infection in Sapporo, Japan

Kei Numazaki  1 , Tomoko Fujikawa
Affiliations

Chronological changes of incidence and prognosis of children with asymptomatic congenital cytomegalovirus infection in Sapporo, Japan

Kei Numazaki et al. BMC Infect Dis. .

Abstract

Background: Chronological changes of the incidence of congenital cytomegalovirus (CMV) infection and the longitudinal prognosis in children with asymptomatic congenital infection were investigated.

Methods: Congenital CMV infection, as demonstrated by isolation of the virus within the first week of life, was diagnosed in infants born in Sapporo, Japan, during the 26-year period between 1977 and 2002.

Results: Congenital infection was diagnosed in 37 (0.31%) of 11,938 infants. Thirty-two infants were (86.5%) asymptomatic and 5 (13.5%) were symptomatic at birth.

Conclusions: Although a decrease in the total incidence of congenital CMV infection has been seen in recent years, screening of congenital infection at birth seems to be necessary to detect late-onset neurodevelopmental sequelae.

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References

    1. Numazaki K, Chiba S. Current aspects of diagnosis and treatment of cytomegalovirus infections in infants. Clin Diagn Virol. 1997;8:169–181. doi: 10.1016/S0928-0197(97)10005-8. - DOI - PubMed
    1. Conboy TJ, Pass RF, Stagno S, Alford CA, Myers GJ, Britt WJ, McCollister FP, Summers MN, McFarland CE, Boll TJ. Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr. 1987;111:343–348. - PubMed
    1. Boppana SB, Fowler KB, Vaid Y, Hedlund G, Stagno S, Britt WJ, Pass RF. Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection. Pediatrics. 1997;99:409–414. - PubMed
    1. Ivarsson S-A, Lernmark B, Svanberg L. Ten-year clinical, developmental, and intellectual follow-up of children with congenital cytomegalovirus infection without neurologic symptoms at one year of age. Pediatrics. 1997;99:800–803. - PubMed
    1. Hirota K, Muraguchi K, Watanabe N, Okumura M, Kozu M, Takahashi K, Machida Y, Funayama Y, Oshima T, Numazaki Y. Prospective study on maternal, intrauterine, and perinatal infections with cytomegalovirus in Japan during 1976–1990. J Med Virol. 1992;37:303–306. - PubMed

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