Comparative Study
doi: 10.1016/j.neures.2004.05.002.
Interactions of bradykinin and norepinephrine on rat cutaneous nociceptors in both normal and inflamed conditions in vitro
Affiliations
- PMID: 15236868
- DOI: 10.1016/j.neures.2004.05.002
Item in Clipboard
Comparative Study
Interactions of bradykinin and norepinephrine on rat cutaneous nociceptors in both normal and inflamed conditions in vitro
Neurosci Res.
2004 Aug.
Abstract
Many inflammatory chemical mediators excite or sensitize nociceptors, which had led some researchers to believe that they may interact with each other to maintain a persistent painful state. We examined how the excitatory mediators norepinephrine (NE) and bradykinin (BK) interact, using single fiber recordings from cutaneous nociceptors. We observed that NE augmented the BK-induced response in both control and adjuvant-inflamed rats in a way different from NE-induced excitation in inflamed animals only. BK also tended to augment the NE-induced response (examined only in inflamed rats). Our results provide the first evidence that BK and NE synergistically interact on nociceptors.
Similar articles
-
Norepinephrine reduces heat responses of cutaneous C-fiber nociceptors in Sprague-Dawley rats in vitro.Neurosci Lett. 2005 Apr 18;378(2):111-6. doi: 10.1016/j.neulet.2004.12.014. Epub 2004 Dec 30. Neurosci Lett. 2005. PMID: 15774268
-
B2 receptor-mediated enhanced bradykinin sensitivity of rat cutaneous C-fiber nociceptors during persistent inflammation.J Neurophysiol. 2001 Dec;86(6):2727-35. doi: 10.1152/jn.2001.86.6.2727. J Neurophysiol. 2001. PMID: 11731532
-
Kainate-induced excitation and sensitization of nociceptors in normal and inflamed rat glabrous skin.Neuroscience. 2006 Feb;137(3):999-1013. doi: 10.1016/j.neuroscience.2005.10.008. Epub 2005 Dec 5. Neuroscience. 2006. PMID: 16330152
-
[Pain and Bradykinin Receptors--sensory transduction mechanism in the nociceptor terminals and expression change of bradykinin receptors in inflamed condition].Nihon Shinkei Seishin Yakurigaku Zasshi. 2005 Feb;25(1):33-8. Nihon Shinkei Seishin Yakurigaku Zasshi. 2005. PMID: 15796068 Review. Japanese.
-
Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals.Brain Res Brain Res Rev. 2004 Oct;46(2):131-45. doi: 10.1016/j.brainresrev.2004.07.015. Brain Res Brain Res Rev. 2004. PMID: 15464202 Review.
Cited by
-
A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation.Brain Behav Immun. 2013 Jan;27(1):174-84. doi: 10.1016/j.bbi.2012.10.013. Epub 2012 Oct 22. Brain Behav Immun. 2013. PMID: 23092711 Free PMC article. Clinical Trial.
-
Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows.J Vet Res. 2018 Oct 24;62(2):193-197. doi: 10.2478/jvetres-2018-0029. eCollection 2018 Jun. J Vet Res. 2018. PMID: 30364907 Free PMC article.
-
Nitric oxide and noradrenaline contribute to the temperature threshold of the axon reflex response to gradual local heating in human skin.J Physiol. 2006 May 1;572(Pt 3):811-20. doi: 10.1113/jphysiol.2005.104067. J Physiol. 2006. PMID: 16497714 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
