doi: 10.1002/ardp.200400867.
Synthesis and antibacterial evaluation of 1beta-methyl-2-(5-substituted heterocyclic carbamoyl)pyrrolidin-3-ylthio)carbapenem derivatives
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- PMID: 15237389
- DOI: 10.1002/ardp.200400867
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Synthesis and antibacterial evaluation of 1beta-methyl-2-(5-substituted heterocyclic carbamoyl)pyrrolidin-3-ylthio)carbapenem derivatives
Arch Pharm (Weinheim).
2004 Jul.
Abstract
The synthesis of a new series of 1beta-methylcarbapenems having a substituted heterocyclic carbamoyl pyrrolidine moiety is described. Their in vitro antibacterial activity against both gram-positive and gram-negative bacteria was tested, and the effect of heterocyclic substituents on the pyrrolidine was investigated. One particular compound (III(d)) having a substituted oxadiazole moiety showed the most potent antibacterial activity.
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