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. 2004 Jun;27(6):338-42.
doi: 10.1002/clc.4960270608.

High remnant lipoprotein levels in patients with variant angina

Kunihisa Miwa  1 , Toshinori Makita, Katsuhisa Ishii, Nobuaki Okuda, Ataru Taniguchi
Affiliations

High remnant lipoprotein levels in patients with variant angina

Kunihisa Miwa et al. Clin Cardiol. 2004 Jun.

Abstract

Background: Dyslipidemia with increased oxidative stress but without elevation of low-density lipoprotein cholesterol has been recently implicated in the pathogenesis of coronary vasospasm.

Hypothesis: Disordered triglyceride-rich lipoprotein metabolism may be linked to the genesis of coronary artery spasm.

Methods: Both serum remnant lipoprotein (RLP) and alpha-tocopherol levels were determined in 18 patients with the active stage of variant angina (VA), in 16 patients with the inactive stage of variant angina (IVA), and in 19 control subjects (CONTROL).

Results: The RLP levels were significantly (p < 0.05) higher in VA (6.4 +/- 2.7 mg/dl) than in IVA (4.4 +/- 1.5 mg/dl). In contrast, alpha-tocopherol levels were significantly lower in VA than that in CONTROL. Serum trigyceride levels were not significantly different among the study groups, although serum high-density lipoprotein cholesterol levels were significantly lower in VA than in CONTROL. Smoking was significantly (p < 0.05) more prevalent in VA (72%) than in IVA (25%) and CONTROL (37%). Serum RLP levels correlated positively with triglyceride levels (R = 0.73) and correlated inversely with alpha-tocopherol levels (R = -0.31) significantly in all study subjects.

Conclusions: Patients with active stage of variant angina had higher RLP levels than inactive patients with variant angina and lower alpha-tocopherol levels than control subjects. Disordered triglyceride-rich lipoprotein metabolism with increased oxidative stress appears to be linked to the activity of coronary vasospasm, suggesting a possible role in its pathogenesis.

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References

    1. Castelli WP, Garrison RJ, Wilson PWF, Abbott RD, Kalousidan S, Kannel WB: Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. J Am Med Assoc 1986; 256: 2835–2838 - PubMed
    1. Frick MH, Elo O, Haapa K, Heinonen OP, Hansalma P, Helo P, Huttunen JK, Kaitaneimi P, Koskinen P, Manninen V, Maenpaa H, Malkonen M, Maittari M, Norola S, Pasternack A, Pikkarainen J, Romo M, Sjoblom T, Nikkila EA: Helsinki Heart Study: Primary prevention trial with gemfibrozil in middle‐aged men with dyslipidemia: Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 1987; 317: 1237–1245 - PubMed
    1. Miwa K, Fujita M, Miyagi Y, Inoue H, Sasayama S: High‐density lipoprotein cholesterol level and smoking modify the prognosis of patients with coronary vasospasm. Clin Cardiol 1995; 18: 267–272 - PubMed
    1. Miwa K, Yoshida N, Nakagawa K, Inoue H: High‐density lipoprotein particles are large in patients with variant angina. Cardiovasc Res 1998; 37: 729–737 - PubMed
    1. Miwa K, Miyagi Y, Fujita M: Susceptibility of plasma low‐density lipoprotein to cupric ion‐induced peroxidation in patients with variant angina. J Am Coll Cardiol 1995; 26: 632–638 - PubMed