doi: 10.1111/j.0300-9475.2004.01449.x.
If the "adaptive" immune system can recognize a significant portion of the pathogenic universe to which the "innate" immune system is blind, then.
Affiliations
- PMID: 15238064
- PMCID: PMC1360149
- DOI: 10.1111/j.0300-9475.2004.01449.x
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If the "adaptive" immune system can recognize a significant portion of the pathogenic universe to which the "innate" immune system is blind, then.
Scand J Immunol.
2004 Jul-Aug.
Abstract
The "adaptive" immune repertoire functionally recognizes pathogens (and their toxic products) that the "innate" defense system misses. This requires that the self-nonself discrimination and the regulation of effector output be dependent primarily on somatic learning mechanisms (i.e. on the somatically generated, large, random "adaptive" immune paratopes repertoire).
Comment in
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Response to Cohn: The immune system rejects the harmful, protects the useful and neglects the rest of microorganisms.Scand J Immunol. 2004 Jul-Aug;60(1-2):3-5; discussion 6-8. doi: 10.1111/j.0300-9475.2004.01451.x. Scand J Immunol. 2004. PMID: 15238065
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References
-
- Medzhitov R, Janeway CA., Jr. Decoding the patterns of Self and Nonself by the innate immune system. Science. 2002;296:298–300. - PubMed
-
- Janeway CA. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today. 1992;13:11–6. - PubMed
-
- Matzinger P. Tolerance, danger and the extended family. Annu Rev Immunol. 1994;12:991–1045. - PubMed
-
- Matzinger P. The real function of the immune system or the four D's (danger, death, destruction, and distress) 2003. http://www.cmngbiosciwayneedu/asg/Polly.html. http://www.cmngbiosciwayneedu/asg/Polly.html retrieved from.
-
- Cohn M. Whither T-suppressors: if they didn't exist would we have to invent them? Cell Immunol. 2004;227:81–92. - PubMed
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