A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children
- PMID: 15238780
- DOI: 10.1097/01.aids.0000131363.82951.fb
A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children
Abstract
In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.
Comment in
-
Are defensin beta 1 gene polymorphisms associated with HIV infection and virus replication?AIDS. 2009 Mar 13;23(5):647-9; author reply 649-50. doi: 10.1097/QAD.0b013e3283277247. AIDS. 2009. PMID: 19516112 No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical