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. 2004 Jul 23;18(11):1598-600.
doi: 10.1097/01.aids.0000131363.82951.fb.

A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children

Laura Braida  1 , Michele Boniotto, Alessandra Pontillo, Pier Angelo Tovo, Antonio Amoroso, Sergio Crovella
Affiliations

A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children

Laura Braida et al. AIDS. .

Abstract

In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.

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