Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004;5(7):231.
doi: 10.1186/gb-2004-5-7-231. Epub 2004 Jun 21.

Analysis of alternative splicing with microarrays: successes and challenges

Christopher Lee  1 , Meenakshi Roy
Affiliations
Review

Analysis of alternative splicing with microarrays: successes and challenges

Christopher Lee et al. Genome Biol. 2004.

Abstract

Recently, DNA microarrays have emerged as potentially powerful tools for analyzing alternative splicing. We briefly review the latest results in this field and highlight the current challenges that they have revealed.

PubMed Disclaimer

References

    1. Jiang ZH, Wu JY. Alternative splicing and programmed cell death. Proc Soc Exp Biol Med. 1999;220:64–72. doi: 10.1046/j.1525-1373.1999.d01-11.x. - DOI - PubMed
    1. Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, Dixon JE, Zipursky SL. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell. 2000;101:671–684. doi: 10.1016/S0092-8674(00)80878-8. - DOI - PubMed
    1. Kriventseva EV, Koch I, Apweiler R, Vingron M, Bork P, Gelfand MS, Sunyaev S. Increase of functional diversity by alternative splicing. Trends Genet. 2003;19:124–128. doi: 10.1016/S0168-9525(03)00023-4. - DOI - PubMed
    1. Lewis BP, Green RE, Brenner SE. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc Natl Acad Sci USA. 2003;100:189–192. doi: 10.1073/pnas.0136770100. - DOI - PMC - PubMed
    1. Modrek B, Lee C. Alternative splicing in the human, mouse and rat genomes is associated with an increased rate of exon creation/loss. Nat Genet. 2003;34:177–180. doi: 10.1038/ng1159. - DOI - PubMed

MeSH terms

LinkOut - more resources