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Review
. 2004 Jul 13;101(28):10241-2.
doi: 10.1073/pnas.0403971101. Epub 2004 Jul 6.

IL-1beta: an endosomal exit

Mark D Wewers  1
Affiliations
Review

IL-1beta: an endosomal exit

Mark D Wewers. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Three proposed pathways to explain IL-1β release from macrophages. (A) Lysis (as with cytolytic cell death). (B) Blebbing (as with the ATP induced extrusion of microvesicles containing IL-1β.(C) Exocytosis (as with the PLA2-mediated exocytosis of lysosomal vesicles, see ref. 6).
Fig. 2.
Fig. 2.
Steps in exosome pathway. Procaspase-1 and pro-IL-1β enter the endosome by a pathway yet to be fully characterized. Loss of intracellular K+ (which can be induced by exogenous ATP) triggers activation of the calcium-independent phosholipase A2 (iPLA2). Endosomal caspase-1 is then activated by the iPLA2 to cleave pro-IL-1β to its functional form. The low intracellular K+ levels also activate phosphatidylcholine phospholipase C (PC-PLC), which induces increases in intracellular calcium (Ca2+). Increased cytosolic Ca2+ activates the calcium-dependent phospholipase A2 (cPLA2) and exocytosis.
See this image and copyright information in PMC

Comment on

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