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Review
. 2004 Jun;5(6):616-22.

Drug-induced destabilization of bcl-2 mRNA: a new approach for inducing apoptosis in tumor cells

Yoko Otake  1 , Tapas K Sengupta, Sumita Bandyopadhyay, Eleanor K Spicer, Daniel J Fernandes
Affiliations
  • PMID: 15242250
Review

Drug-induced destabilization of bcl-2 mRNA: a new approach for inducing apoptosis in tumor cells

Yoko Otake et al. Curr Opin Investig Drugs. 2004 Jun.

Abstract

Recent evidence suggests that the 3' untranslated region (3' UTR) of some mRNAs is a molecular hotspot for pathology. The 3' UTR of bcl-2 mRNA contains several AU-rich elements (AREs) that promote mRNA destabilization. Recent studies have demonstrated that the protein, nucleolin, binds to an ARE in bcl-2 mRNA, thereby protecting this mRNA from nuclease degradation. All-trans retinoic acid, taxol and okadiac acid induce downregulation or inactivation of nucleolin, which destabilizes bcl-2 mRNA and triggers apoptosis. The ARE instability elements in bcl-2 mRNA are potential therapeutic targets for inducing apoptosis and overcoming drug resistance in cancer cells.

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