Genetic relatedness and quinolone resistance of Campylobacter jejuni strains isolated in 2002 in Hong Kong

Abstract

Pulsed-field gel electrophoresis fingerprints of 98 Campylobacter jejuni isolates from patients (85) and chicken carcasses (13) in Hong Kong in 2002 demonstrated high genetic diversity. The prevalence of quinolone resistance among the isolates was 85.9%, and replacement of the threonine-86 residue in the gyrase subunit A was the major resistance mechanism.

FIG. 1.

Dendrogram constructed by unweighted pair group method with averages from a Dice coefficient matrix showing the relatedness of the PFGE SmaI fingerprints of 98 C. jejuni strains isolated in 2002 in Hong Kong. The band patterns were digitally represented, and the band position tolerance was 1.0%. The first column is cluster designation, the second is isolation date, the third is specimen type, the fourth is resistance phenotype, and the fifth is the amino acid at residue 86 of the gyrase subunit A. nd, not determined.