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Comparative Study
. 2004 Aug 1;190(3):515-8.
doi: 10.1086/421523. Epub 2004 Jul 7.

Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome

Margaret H L Ng  1 , Kin-Mang Lau, Libby Li, Suk-Hang Cheng, Wing Y Chan, Pak K Hui, Benny Zee, Chi-Bon Leung, Joseph J Y Sung
Affiliations
Comparative Study

Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome

Margaret H L Ng et al. J Infect Dis. .

Abstract

Severe acute respiratory syndrome (SARS) is a public health concern worldwide. By studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in 90 Chinese patients with serologically confirmed SARS infections, we identified a strong association between HLA-B*0703 (OR, 4.08; 95% CI, 2.03-8.18; P=.00072 [Bonferroni-corrected P value, P(c) <.0022]) and -DRB1*0301 (OR, 0.06; 95%, 0.01-0.47; P=.00008 [after Bonferroni correction, P<.0042]) and the development of SARS. Moreover, the frequency of B*0703 and B60 coinheritance (9.6%; 95% CI, 4.6%-19.0%) in our SARS group was significantly higher (P=3x10(-9)) than that expected in the general population (0.4%). These genetic data will critically affect both the study of the pathogenesis of SARS and the design of vaccination programs.

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Figures

Table 1.
Table 1.
Frequency of HLA A, B, DR, and DQ alleles in Hong Kong Chinese patients with SARS and in the overall Hong Kong Chinese population.
Table 1.
Table 1.
Frequency of HLA A, B, DR, and DQ alleles in Hong Kong Chinese patients with SARS and in the overall Hong Kong Chinese population.
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