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Case Reports
. 1992;35(2):110-2.

Trisomy 16 confined to chorionic villi and unfavourable outcome of pregnancy

G Simoni  1 , B Brambati, F Maggi, L Jackson
Affiliations
  • PMID: 1524407
Case Reports

Trisomy 16 confined to chorionic villi and unfavourable outcome of pregnancy

G Simoni et al. Ann Genet. 1992.

Abstract

Two cases of trisomy 16 confined to placental tissue associated with an unfavourable outcome of the pregnancy are reported. In the first case, after a diagnosis of an apparent non-mosaic trisomy 16 at chorionic villi sample (CVS), an intrauterine fetal death occurred at the 22nd week. In the second case a mosaic with trisomy 16 was found in chorionic villi and the fetus was still-born at 38 weeks. From a comparison of their cases with those of the literature, the authors conclude that a trisomy 16 confined to placental tissue has a negative effect on fetal growth and pregnancy outcome.

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