Review
doi: 10.1016/j.coi.2004.05.007.
Heat-shock proteins and the host-pathogen interaction during bacterial infection
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- PMID: 15245747
- DOI: 10.1016/j.coi.2004.05.007
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Review
Heat-shock proteins and the host-pathogen interaction during bacterial infection
Curr Opin Immunol.
2004 Aug.
Abstract
Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during adaptation to intracellular survival. Both host and pathogen heat-shock proteins contribute to immunity by receptor-mediated activation of the innate immune response and by participation in the presentation of antigens for the adaptive immune response. Manipulation of these interactions presents a potential route to improved control of infection by vaccination or immunotherapy.
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