Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Jun:1019:245-55.
doi: 10.1196/annals.1297.041.

Genomic instability, aging, and cellular senescence

Rita A Busuttil  1 , Martijn Dollé, Judith Campisi, Jan Vijga
Affiliations
Review

Genomic instability, aging, and cellular senescence

Rita A Busuttil et al. Ann N Y Acad Sci. 2004 Jun.

Abstract

Aging can be defined in practical terms as a series of time-related processes that ultimately bring life to a close. Genomic instability has been implicated as a major causal factor in aging. Here, we describe the use of a transgenic mouse model, harboring lacZ reporter genes as part of a plasmid construct integrated at one or more chromosomal locations, to study genomic instability during aging of different mouse organs and tissues as well as in mouse embryonic fibroblasts during primary culture.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms.
    Beck J, Turnquist C, Horikawa I, Harris C. Beck J, et al. Carcinogenesis. 2020 Aug 12;41(8):1017-1029. doi: 10.1093/carcin/bgaa071. Carcinogenesis. 2020. PMID: 32619002 Free PMC article. Review.
  • Bypassing cellular senescence by genetic screening tools.
    Vergel M, Carnero A. Vergel M, et al. Clin Transl Oncol. 2010 Jun;12(6):410-7. doi: 10.1007/s12094-010-0528-2. Clin Transl Oncol. 2010. PMID: 20534396 Review.
  • Biomarkers of aging.
    Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo OJ, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y, Wang Y, Wu R, Xia K, Xiao FH, Xu L, Xu Y, Yan H, Yang L, Yang R, Yang Y, Ying Y, Zhang L, Zhang W, Zhang W, Zhang X, Zhang Z, Zhou M, Zhou R, Zhu Q, Zhu Z, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen HZ, Chen J, Ci W, Ding BS, Ding Q, Gao F, Han JJ, Huang K, Ju Z, Kong QP, Li J, Li J, Li X, Liu B, Liu F, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren J, Ren R, Song M, Songyang Z, Sun YE, Sun Y, Tian M, Wang S, Wang S, Wang X, Wang X, Wang YJ, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xie Z, Xu D, Ye J, Yue R, Zhang C, Zhang H, Zhang L, Zhang W, Zhang Y, Zhang YW, Zhang Z, Zhao T, Zhao Y, Zhu D, Zou W, Pei G, Liu GH. Aging Biomarker Consortium, et al. Sci China Life Sci. 2023 May;66(5):893-1066. doi: 10.1007/s11427-023-2305-0. Epub 2023 Apr 11. Sci China Life Sci. 2023. PMID: 37076725 Free PMC article. Review.
  • DNA damage, cellular senescence and organismal ageing: causal or correlative?
    Chen JH, Hales CN, Ozanne SE. Chen JH, et al. Nucleic Acids Res. 2007;35(22):7417-28. doi: 10.1093/nar/gkm681. Epub 2007 Oct 2. Nucleic Acids Res. 2007. PMID: 17913751 Free PMC article. Review.
  • Fragile DNA repair mechanism reduces ageing in multicellular model.
    Bendtsen KM, Juul J, Trusina A. Bendtsen KM, et al. PLoS One. 2012;7(5):e36018. doi: 10.1371/journal.pone.0036018. Epub 2012 May 2. PLoS One. 2012. PMID: 22567122 Free PMC article.
See all "Cited by" articles

LinkOut - more resources