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Clinical Trial
. 2004 Aug;10(8):811-3.
doi: 10.1038/nm1077. Epub 2004 Jul 11.

A role for Streptococcus pneumoniae in virus-associated pneumonia

Shabir A Madhi  1 , Keith P Klugman; Vaccine Trialist Group
Affiliations
Clinical Trial

A role for Streptococcus pneumoniae in virus-associated pneumonia

Shabir A Madhi et al. Nat Med. 2004 Aug.

Abstract

Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15-43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia.

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Conflict of interest statement

Vaccine trial was funded by Wyeth.

References

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