Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jul;99(7):583-6.
doi: 10.1111/j.1471-0528.1992.tb13825.x.

CIN 3: the role of lesion size in invasion

P Tidbury  1 , A Singer, D Jenkins
Affiliations

CIN 3: the role of lesion size in invasion

P Tidbury et al. Br J Obstet Gynaecol. 1992 Jul.

Abstract

Objective: To define the relation between the size of a CIN 3 lesion (measured histologically) and invasive squamous carcinoma.

Design: Measurement of CIN 3 by computerized planimetry of histological sections from 39 cone biopsies containing microinvasive cancer. Comparison with previous measurements of CIN lesions, associated with different grades of dyskaryosis.

Results: Microinvasive carcinoma of the cervix is associated with extensive CIN 3 on the surface and in endocervical crypts. The mean size of CIN 3 lesions showing microinvasion is seven times greater than that for severe dyskaryosis without invasion, (P less than 0.0001) and a 100-fold greater than with mild dyskaryosis (P less than 0.00001).

Conclusion: Invasive squamous carcinoma of the cervix arises in large CIN 3 lesions and these are associated usually with severe dyskaryosis. We propose a model for the development of high-grade precancer as a small focus within low grade precancer which then undergoes expansion in size, accompanied by apparent progression in cytological grade.

PubMed Disclaimer