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Comment

. 2004 Jul 20;101(29):10496-7.

doi: 10.1073/pnas.0404066101. Epub 2004 Jul 13.

In defense of the cell: TRIM5alpha interception of mammalian retroviruses

Kyeongeun Lee¹, Vineet N KewalRamani

Affiliations

PMID: 15252204
PMCID: PMC489964
DOI: 10.1073/pnas.0404066101

Comment

In defense of the cell: TRIM5alpha interception of mammalian retroviruses

Kyeongeun Lee et al. Proc Natl Acad Sci U S A. 2004.

. 2004 Jul 20;101(29):10496-7.

doi: 10.1073/pnas.0404066101. Epub 2004 Jul 13.

Authors

Kyeongeun Lee¹, Vineet N KewalRamani

Affiliation

¹ Model Development Section, HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

PMID: 15252204
PMCID: PMC489964
DOI: 10.1073/pnas.0404066101

No abstract available

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Figures

Fig. 1. — Fig. 1.
Antiviral fusillade. Fv1, TRIM1, or TRIM5α restriction of N-MLV (blue), B-MLV (green), SIV_mac. (lavender), or HIV-1 (red). Boxes indicate species-specific restrictive measures targeting invading retroviral particles. h, Human; rh, rhesus macaque; agm, African green monkey; omk, owl monkey kidney.

See this image and copyright information in PMC

Comment on

Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha.
Hatziioannou T, Perez-Caballero D, Yang A, Cowan S, Bieniasz PD. Hatziioannou T, et al. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10774-9. doi: 10.1073/pnas.0402361101. Epub 2004 Jul 12. Proc Natl Acad Sci U S A. 2004. PMID: 15249685 Free PMC article.
The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities.
Keckesova Z, Ylinen LM, Towers GJ. Keckesova Z, et al. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10780-5. doi: 10.1073/pnas.0402474101. Epub 2004 Jul 12. Proc Natl Acad Sci U S A. 2004. PMID: 15249687 Free PMC article.
Trim5alpha protein restricts both HIV-1 and murine leukemia virus.
Yap MW, Nisole S, Lynch C, Stoye JP. Yap MW, et al. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10786-91. doi: 10.1073/pnas.0402876101. Epub 2004 Jul 12. Proc Natl Acad Sci U S A. 2004. PMID: 15249690 Free PMC article.

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References

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1. Johnson, W. E. & Coffin, J. M. (1999) Proc. Natl. Acad. Sci. USA 96, 10254–10260. - PMC - PubMed
1. Yap, M. W., Nisole, S., Lynch, C. & Stoye, J. P. (2004) Proc. Natl. Acad. Sci. USA 101, 10786–10791. - PMC - PubMed
1. Hatziioannou, T., Perez-Caballero, D., Yang, A., Cowan, S. & Bieniasz, P. D. (2004) Proc. Natl. Acad. Sci. USA 101, 10774–10779. - PMC - PubMed
1. Keckesova, Z., Ylinen, L. M. J. & Towers, G. J. (2004) Proc. Natl. Acad. Sci. USA 101, 10780–10785. - PMC - PubMed

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