Comparative Study
Effects of oestrogen on mitochondrial thymidine kinase activity in the immature rat uterus
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- PMID: 1525336
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Comparative Study
Effects of oestrogen on mitochondrial thymidine kinase activity in the immature rat uterus
In Vivo.
1992 Mar-Apr.
Abstract
Thymidine kinase (TK) is a key enzyme in the pyrimidine salvage pathway. High TK activity and the existence of cytosolic isozyme have consistently been observed in rapidly proliferating tissues. Oestrogen treatment induces the moderate increase of activities of mitochondrial TK and the fetal type TK isozyme in immature rat uterus. These results indicate that oestrogen induces the increase of uterine DNA synthesis in both cytosol and mitochondria in immature rats.
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