Formation of PAF-like compounds by peroxidation of phospholipids from bovine brain
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- PMID: 1525352
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Formation of PAF-like compounds by peroxidation of phospholipids from bovine brain
J Lipid Mediat.
1992 Jun-Jul.
Abstract
This short review describes the identification by mass spectrometry of phospholipids having an sn-2-short-chain monocarboxylate, dicarboxylate or omega-hydroxycarboxylate group in a fraction with PAF-like activity from a bovine brain lipid extract. The similar molecular heterogeneities of these unique phospholipids suggest that they are formed via a common mechanism, possibly peroxidation of membrane phosphatidylcholines. This possibility is supported by the finding that these PAF-like compounds were actually formed during peroxidation of synthetic phosphatidylcholines induced by Fe2+/ascorbate/EDTA.
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