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Review
. 2004 Aug;78(15):7867-73.
doi: 10.1128/JVI.78.15.7867-7873.2004.

Innate sensing of viruses by toll-like receptors

Karl W Boehme  1 , Teresa Compton
Affiliations
Review

Innate sensing of viruses by toll-like receptors

Karl W Boehme et al. J Virol. 2004 Aug.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Schematic of TLR signaling pathways. TLR2 (in combination with TLR1 or TLR6) and TLR4 utilize MyD88 and TIRAP/MAL as primary adaptors to activate NF-κB and inflammatory cytokine secretion. Also, TLR4 uses TRIF and the TRIF-related adaptor molecule (TRAM) to activate IRF3 and the IFN pathway. TLRs 3, 7, 8, and 9 typically localize to endocytic compartments, where they detect a variety of nucleic acids and activate the IFN pathway. TLR3 utilizes TRIF, but not TRAM, to activate IRF3. TLRs 7, 8, and 9 trigger inflammatory cytokine secretion and the IFN pathway through MyD88. Other than MyD88, the signaling intermediates utilized by TLRs 7, 8, and 9 to activate IFN responses remain undefined.
See this image and copyright information in PMC

References

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