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. 2003 Feb;41(2):181-3.

Effect of methanolic leaf extract of Cissampelos mucronata A. Rich against indomethacin induced ulcer in rats

S V Nwafor  1 , P A Akah
Affiliations
  • PMID: 15255614

Effect of methanolic leaf extract of Cissampelos mucronata A. Rich against indomethacin induced ulcer in rats

S V Nwafor et al. Indian J Exp Biol. 2003 Feb.

Abstract

Five fractions (F1-F5) isolated from the methanolic leaf extract of Cissampelos mucronata A. Rich were investigated for antiulcer activity. At the dose of 450 mg/kg, they showed varying degree of protection against ulcer induced by indomethacin; the order of protection being F1>F4>F5>F2>F3. The antiulcer potency of F1 and F2 is comparable with that of cimetidine (100 mg/kg, i.p.). Inhibition of gastric mucosal damage may partly contribute to the antiulcer activity of the fractions.

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