Transfer of adaptation from visually guided saccades to averaging saccades elicited by double visual targets

Abstract

The adaptive mechanisms that control the amplitude of visually guided saccades (VGS) are only partially elucidated. In this study, we investigated, in six human subjects, the transfer of VGS adaptation to averaging saccades elicited by the simultaneous presentation of two visual targets. The generation of averaging saccades requires the transformation of two representations encoding the desired eye displacement toward each of the two targets into a single representation encoding the averaging saccade (averaging programming site). We aimed to evaluate whether VGS adaptation acts upstream (hypothesis 1) or at/below (hypothesis 2) the level of averaging saccades programming. Using the double-step target paradigm, we simultaneously induced a backward adaptation of 17.5 degrees horizontal VGS and a forward adaptation of 17.5 degrees oblique VGS performed along the +/- 40 degrees directions relative to the azimuth. We measured the effects of this dual adaptation protocol on averaging saccades triggered by two simultaneous targets located at 17.5 degrees along the +/- 40 degrees directions. To increase the yield of averaging saccades, we instructed the subjects to move their eyes as fast as possible to an intermediate position between the two targets. We found that the amplitude of averaging saccades was smaller after VGS adaptation than before and differed significantly from that predicted by hypothesis 1, but not by hypothesis 2, with an adaptation transfer of 50%. These findings indicate that VGS adaptation largely occurs at/below the averaging saccade programming site. Based on current knowledge of the neural substrate of averaging saccades, we suggest that VGS adaptation mainly acts at the level of the superior colliculus or downstream.