Editorial
doi: 10.1016/j.molcel.2004.07.002.
The Making of an siRNA
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- PMID: 15260964
- DOI: 10.1016/j.molcel.2004.07.002
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Editorial
The Making of an siRNA
Mol Cell.
.
Free article
Abstract
An array of gene silencing pathways share a common early step: Dicer cleaves double-stranded RNA (dsRNA) into approximately 20-25 nucleotide fragments that direct the silencing machinery to specific targets. A recent report in Cell reveals how Dicer's two RNase III domains collaborate during dsRNA processing and sets the stage for a deeper understanding of Dicer's roles in later phases of silencing complex assembly.
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