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Review
. 2004 Jul 23;118(2):140-1.
doi: 10.1016/j.cell.2004.07.005.

Regulation of WASP: PIP2 Pipped by Toca-1?

Robert H Insall  1 , Laura M Machesky
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Free article
Review

Regulation of WASP: PIP2 Pipped by Toca-1?

Robert H Insall et al. Cell. .
Free article

Abstract

Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP. This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility.

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