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. 2004 Aug 16;14(16):4245-8.
doi: 10.1016/j.bmcl.2004.06.008.

Aminotriazine 5-HT7 antagonists

Ronald J Mattson  1 , Derek J Denhart, John D Catt, Michael F Dee, Jeffrey A Deskus, Jonathan L Ditta, James Epperson, H Dalton King, Aiming Gao, Michael A Poss, Ashok Purandare, David Tortolani, Yufen Zhao, Hua Yang, Suresh Yeola, Jane Palmer, John Torrente, Arlene Stark, Graham Johnson
Affiliations

Aminotriazine 5-HT7 antagonists

Ronald J Mattson et al. Bioorg Med Chem Lett. .

Abstract

The present studies have identified a series of aminotriazines as novel 5-HT(7) receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT(7) receptor and do not bind to either the 5-HT(2C) or 5-HT(6) receptors. These compounds produce no agonist effects by themselves, and shift the dose-response curve of 5-CT to the right in the manner of an antagonist.

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