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. 1992 Sep 21;310(1):31-3.
doi: 10.1016/0014-5793(92)81139-d.

IL-4 inhibits LPS-, IL-1 beta- and TNF alpha-induced expression of tissue factor in endothelial cells and monocytes

J M Herbert  1 , P Savi, M C Laplace, A Lale
Affiliations
Free article

IL-4 inhibits LPS-, IL-1 beta- and TNF alpha-induced expression of tissue factor in endothelial cells and monocytes

J M Herbert et al. FEBS Lett. .
Free article

Abstract

Inflammatory mediators such as endotoxin, interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) dose-dependently increased the expression of tissue factor on the surface of cultured bovine aortic endothelial cells (ABAE), human umbilical vein endothelial cells (HUVEC) and human monocytes. In ABAE, endotoxin-, IL-1 beta- and TNF alpha-induced tissue factor expression was suppressed by interleukin-4 (IL-4) which also neutralized the pyrogenic effect of endotoxin in HUVEC and monocytes. IL-4 did not alter TNF-alpha-induced procoagulant changes in HUVEC and monocytes but strongly protected the monocyte surface against IL-1 beta-induced procoagulant changes.

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