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. 1992 Aug 15;74(2-3):195-9.
doi: 10.1016/0378-1097(92)90428-q.

Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability

L S Tzouvelekis  1 , E Tzelepi, A F Mentis, A C Vatopoulos, A Tsakris
Affiliations

Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability

L S Tzouvelekis et al. FEMS Microbiol Lett. .

Abstract

Enterobacter aerogenes mutants with high-level resistance to imipenem were studied. They were derived from strains characterized by stable over-production of a class-I beta-lactamase. This enzyme (pI = 8.2) exhibited high affinity toward imipenem and hydrolysed the drug slowly. Imipenem-resistant mutants lacked a major 43-kDa outer membrane protein and displayed decreased permeability to cephaloridine. Introduction of a plasmid coding for the regulatory ampD gene abolished beta-lactamase production and rendered the mutants susceptible to imipenem.

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