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Review
. 2004 Aug;142(8):1203-7.
doi: 10.1038/sj.bjp.0705888. Epub 2004 Jul 20.

The NAADP receptor: commentary on Billington et al

A Galione  1 , J Parrington, J Dowden
Affiliations
Review

The NAADP receptor: commentary on Billington et al

A Galione et al. Br J Pharmacol. 2004 Aug.

Abstract

NAADP is a recently described calcium-mobilizing messenger. First discovered as a potent calcium-releasing molecule in sea urchin eggs, its actions have now been reported in several mammalian cell types. In the sea urchin egg, NAADP-sensitive calcium release channels appear distinct from inositol trisphosphate or ryanodine receptors, and are mainly localized to acidic compartments. In this study, Billington et al. extend the pharmacology of the putative NAADP receptor utilizing molecules unrelated to NAADP itself. This work may provide an important step in developing selective NAADP receptor modulators that will help define the role of NAADP in cell signalling.

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Figures

Figure 1
Figure 1
Structure–activity relationships for NAADP and structural analogues. Concentrations refer to approximate EC50s for calcium release in sea urchin egg homogenates.
See this image and copyright information in PMC

Comment on

  • Triazine dyes are agonists of the NAADP receptor.
    Billington RA, Bak J, Martinez-Coscolla A, Debidda M, Genazzani AA. Billington RA, et al. Br J Pharmacol. 2004 Aug;142(8):1241-6. doi: 10.1038/sj.bjp.0705886. Epub 2004 Jul 20. Br J Pharmacol. 2004. PMID: 15265807 Free PMC article.

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