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Review
. 2004 Aug 15;129A(1):83-6.
doi: 10.1002/ajmg.a.20668.

Choanal atresia associated with prenatal methimazole exposure: three new patients

P Barbero  1 , C Ricagni, G Mercado, R Bronberg, M Torrado
Affiliations
Review

Choanal atresia associated with prenatal methimazole exposure: three new patients

P Barbero et al. Am J Med Genet A. .

Abstract

We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus.

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