doi: 10.1111/j.1365-2184.1978.tb00819.x.
Purification of immunosuppressive factors extracted from bovine spleen (lymphoid chalone). II. Biological activity
- PMID: 152670
- DOI: 10.1111/j.1365-2184.1978.tb00819.x
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Purification of immunosuppressive factors extracted from bovine spleen (lymphoid chalone). II. Biological activity
Cell Tissue Kinet.
1978 Sep.
Abstract
A highly purified extract from bovine spleen (FA) possessing immunosuppressive capacity was studied. Its tissue specificity was analysed in vivo and in vitro and the main components of FA, the well-known nucleosides deoxycytidine, deoxyinosine and thymidine, were tested in vivo. It seems that the molecule responsible for the biological activity of FA is a new substance endowed with strong specific activity and that lymphoid tissue is highly sensitive to the inhibiting capacity of this purified fraction.
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