[Studies on sex hormone-binding globulin in the prostate]

Abstract

Objective: To assay the existence of SHBG in prostatic tissue and analyze the effects of SHBG on the prostate and prostatic hyperplasia.

Methods: Prostate tissue cytosolic and nuclear fractions were obtained from 32 cases of benign prostatic hyperplasia (BPH), 11 cases of elderly control, and 22 cases of the normal young and middle-aged. SHBG in cytosol and nucleus was evaluated by two-site immunoradiometric assay based on the 125I-labelled monoclonal antibody.

Results: The study testified the existence of SHBG in the cytosol of prostatic tissue. SHBG in BPH tissue [(5.11 +/- 1.37) fmol/g wet tissue] was a little more than that in the young and middle-aged group [(4.98 +/- 1.39) fmol/g wet tissue] and the elderly group [(5.06 +/- 1.27) fmol/g wet tissue], but there was no significance among the three groups (P > 0.05).

Conclusion: SHBG in the prostate can bind and accumlate androgen, which is related to prostatic physiology and contributes to the etiology of BPH.