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Review
. 2004 Aug;3(4):161-7.
doi: 10.1111/j.1474-9728.2004.00102.x.

Innate immunity in aging: impact on macrophage function

Julie Plowden  1 , Mary Renshaw-Hoelscher, Carrie Engleman, Jacqueline Katz, Suryaprakash Sambhara
Affiliations
Free article
Review

Innate immunity in aging: impact on macrophage function

Julie Plowden et al. Aging Cell. 2004 Aug.
Free article

Abstract

Innate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as 'pathogen sensors' and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.

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