Review
doi: 10.1111/j.1474-9728.2004.00102.x.
Innate immunity in aging: impact on macrophage function
Affiliations
- PMID: 15268749
- DOI: 10.1111/j.1474-9728.2004.00102.x
Item in Clipboard
Review
Innate immunity in aging: impact on macrophage function
Aging Cell.
2004 Aug.
Free article
Abstract
Innate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as 'pathogen sensors' and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.
Similar articles
-
Innate immunity and angiogenesis.Circ Res. 2005 Jan 7;96(1):15-26. doi: 10.1161/01.RES.0000153188.68898.ac. Circ Res. 2005. PMID: 15637304 Review.
-
Signal transduction and functional changes in neutrophils with aging.Aging Cell. 2004 Aug;3(4):217-26. doi: 10.1111/j.1474-9728.2004.00110.x. Aging Cell. 2004. PMID: 15268755 Review.
-
[Frontier of mycobacterium research--host vs. mycobacterium].Kekkaku. 2005 Sep;80(9):613-29. Kekkaku. 2005. PMID: 16245793 Japanese.
-
Innate immunity: cells, receptors, and signaling pathways.Arch Immunol Ther Exp (Warsz). 2005 May-Jun;53(3):245-53. Arch Immunol Ther Exp (Warsz). 2005. PMID: 15995585 Review.
-
Toll-like receptors in innate immunity.Int Immunol. 2005 Jan;17(1):1-14. doi: 10.1093/intimm/dxh186. Int Immunol. 2005. PMID: 15585605 Review.
Cited by
-
Src is required for migration, phagocytosis, and interferon beta production in Toll-like receptor-engaged macrophages.Biomedicine (Taipei). 2016 Jun;6(3):14. doi: 10.7603/s40681-016-0014-4. Epub 2016 Aug 12. Biomedicine (Taipei). 2016. PMID: 27514533 Free PMC article.
-
Immunotherapy in Elderly Patients Affected by Non-Small Cell Lung Cancer: A Narrative Review.J Clin Med. 2023 Feb 24;12(5):1833. doi: 10.3390/jcm12051833. J Clin Med. 2023. PMID: 36902620 Free PMC article. Review.
-
Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function.Elife. 2023 Apr 25;12:e74915. doi: 10.7554/eLife.74915. Elife. 2023. PMID: 37096871 Free PMC article.
-
Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation.Immun Ageing. 2015 Oct 29;12:18. doi: 10.1186/s12979-015-0045-9. eCollection 2015. Immun Ageing. 2015. PMID: 26516334 Free PMC article.
-
Immunosenescence and organ transplantation.Transplant Rev (Orlando). 2013 Jul;27(3):65-75. doi: 10.1016/j.trre.2013.03.001. Epub 2013 Apr 30. Transplant Rev (Orlando). 2013. PMID: 23639337 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
