Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2004 Apr;21(4):103-7.
doi: 10.1023/b:jarg.0000029493.54929.be.

Monozygotic twins and triplets in association with blastocyst transfer

John K Jain  1 , Robert Boostanfar, Cristin C Slater, Mary M Francis, Richard J Paulson
Affiliations
Comparative Study

Monozygotic twins and triplets in association with blastocyst transfer

John K Jain et al. J Assist Reprod Genet. 2004 Apr.

Abstract

Purpose: To compare the incidence of monozygotic twins following blastocyst versus day-3 embryo transfer (ET).

Methods: A retrospective analysis of the outcome of assisted reproductive technology (ART) cycles utilizing blastocyst ET during 1999-2000 was compared to a similar group of patients undergoing day-3 ET during 1997-1998.

Results: Blastocyst ET was used in 75 cycles with 2.0 +/- 2 embryos transferred. The comparison group consisted of 90 cycles with day-3 ET and 3.0 +/- 2 embryos transferred.

Conclusions: High pregnancy rates are maintained with blastocyst ET even though fewer embryos are transferred. The rate of monozygotic twins is higher with blastocyst ET than with day-3 ET. This increase may partially negate the benefit of reduced high-order multiple gestations attributed to blastocyst ET.

PubMed Disclaimer

References

    1. Society for Assisted Reproductive TechnologyThe American Society for Reproductive Medicine Assisted Reproductive Technology in the United States 1999 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril. 2002;71:798–807. - PubMed
    1. Kolibianakis EM, Devroey P. Blastocyst culture: Facts and fiction. Reprod Biomed Online. 2000;5:285–293. - PubMed
    1. Schoolcraft WB, Gardner DK, Lane M, Schlenker MA, Hamilton F, Meldrum DR. Blastocyst culture and transfer: Analysis of results and parameters affecting outcome in two in vitro fertilization programs. Fertil Steril. 1999;72:604–609. - PubMed
    1. Peramo B, Ricciarelli E, Cuadros-Fernandez JM, Huguet E, Hernandez ER. Blastocyst transfer and monozygotic twinning. Fertil Steril. 1999;72:1116–1117. - PubMed
    1. Rijnders PM, van Os HC, Jansen CAM. Increased incidence of monozygotic twinning following the transfer of blastocysts in human IVF/ICSI. Fertil Steril. 1998;70(1):S15–S16.

Publication types