Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Dec 1;129(4):273-8.
doi: 10.1007/BF00441358.

Delayed cutaneous hypersensitivity in children with severe multiple handicaps treated with phenytoin

A Higashi, I Matsuda, S Sinosuka, H Ohtsuka, F Endo, T Maeda, T Ikeda, S Miyoshino

Delayed cutaneous hypersensitivity in children with severe multiple handicaps treated with phenytoin

A Higashi et al. Eur J Pediatr. .

Abstract

Peripheral lymphocyte counts, T-cell and B-cell populations, DNCB skin reactions, Mantoux reactions, mitogenic transformation using PHA, and determination of serum phenytoin concentration were carried out in 45 children with severe handicaps. Twenty two of these patients were receiving phenytoin treatment. When compared with control subjects, the skin reactions were significantly depressed in the handicapped children, amongst whom those treated with phenytoin had more impaired reactions than those who were untreated. No significant relationship between the results of the skin reactions and the other parameters was found.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Lancet. 1972 Dec 30;2(7792):1425 - PubMed
    1. Am J Dis Child. 1976 Mar;130(3):316-9 - PubMed
    1. Br Med J. 1972 Jun 3;2(5813):561-3 - PubMed
    1. J Lab Clin Med. 1976 Sep;88(3):417-22 - PubMed
    1. J Immunol. 1972 Apr;108(4):1080-7 - PubMed