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Review
. 2004 Aug;137(2):225-33.
doi: 10.1111/j.1365-2249.2004.02561.x.

Autoimmune polyglandular syndrome Type 2: the tip of an iceberg?

C Betterle  1 , F Lazzarotto, F Presotto
Affiliations
Review

Autoimmune polyglandular syndrome Type 2: the tip of an iceberg?

C Betterle et al. Clin Exp Immunol. 2004 Aug.

Abstract

Autoimmune polyglandular syndromes (APS) are conditions characterized by the association of two or more organ-specific disorders. Type 2 APS is defined by the occurrence of Addison's disease with thyroid autoimmune disease and/or Type 1 diabetes mellitus. Clinically overt disorders are considered only the tip of the autoimmune iceberg, since latent forms are much more frequent. Historical, clinical, genetic, and immunological aspects of Type 2 APS are reviewed. Furthermore, data on 146 personal cases of Type 2 APS are also reported.

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References

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