Review
doi: 10.1016/j.tins.2004.05.004.
Presynaptic induction and expression of NMDA-dependent LTP
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- PMID: 15271488
- DOI: 10.1016/j.tins.2004.05.004
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Review
Presynaptic induction and expression of NMDA-dependent LTP
Trends Neurosci.
2004 Aug.
Abstract
It is almost axiomatic in neuroscience that postsynaptically induced NMDA-dependent long-term potentiation (LTP) is a cellular substrate of memory. As a result, memory impairments caused by experimental reductions of NMDA currents are often interpreted as evidence that this form of plasticity is involved in memory formation. However, a recent Nature study indicates that not all NMDA-dependent LTP is induced postsynaptically.
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