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. 2004 Aug;72(8):4864-7.
doi: 10.1128/IAI.72.8.4864-4867.2004.

The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease

Jon S Blevins  1 , Andrew T Revel, Melissa J Caimano, Xiaofeng F Yang, James A Richardson, Kayla E Hagman, Michael V Norgard
Affiliations

The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease

Jon S Blevins et al. Infect Immun. 2004 Aug.

Abstract

luxS mutants of Borrelia burgdorferi strain 297 naturally colonized their arthropod (Ixodes scapularis) vector, were maintained in ticks throughout the molting process (larvae to nymphs), were tick transmitted to uninfected mice, and elicited histopathology in mice indistinguishable from that induced by wild-type B. burgdorferi.

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Figures

FIG. 1.
FIG. 1.
Histopathology of cardiac and knee tissues from mice infected with either wild-type B. burgdorferi strain 297 (Bb297) or the luxS mutant BbAH308. Results were identical for the luxS mutant BbAH309. Arrows denote areas of pronounced immune cell infiltration.
See this image and copyright information in PMC

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