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. 2004 Jul;86(5):696-700.
doi: 10.1302/0301-620x.86b5.14747.

Genetic influences in the aetiology of tears of the rotator cuff. Sibling risk of a full-thickness tear

P Harvie  1 , S J Ostlere, J Teh, E G McNally, K Clipsham, B J Burston, T C B Pollard, A J Carr
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Genetic influences in the aetiology of tears of the rotator cuff. Sibling risk of a full-thickness tear

P Harvie et al. J Bone Joint Surg Br. 2004 Jul.

Abstract

From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63). The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.

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