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Review
. 2004 Aug;12(8):356-60.
doi: 10.1016/j.tim.2004.06.005.

EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies

Pierre Busson  1 , Cécile Keryer, Tadamassa Ooka, Marilys Corbex
Affiliations
Review

EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies

Pierre Busson et al. Trends Microbiol. 2004 Aug.

Abstract

Nasopharyngeal carcinoma is a human malignancy consistently associated with the Epstein-Barr virus. Exposure to non-viral carcinogens and genetic predisposition are other crucial etiologic factors. Tumor development appears to require the expression of a small subset of transforming viral RNAs and proteins with concomitant silencing of most other viral genes. Impairment of the interactions of viral proteins with cellular partners or disruption of viral latency might prove to be useful for novel therapeutic strategies.

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